{"id":271,"date":"2023-11-25T12:57:09","date_gmt":"2023-11-25T12:57:09","guid":{"rendered":"https:\/\/www.mct8.info\/?page_id=271"},"modified":"2024-05-05T07:08:49","modified_gmt":"2024-05-05T07:08:49","slug":"investigacion-cientifica","status":"publish","type":"page","link":"https:\/\/www.mct8.info\/es\/investigacion-cientifica\/","title":{"rendered":"Investigaci\u00f3n cient\u00edfica"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">Ensayos cl\u00ednicos en curso<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">Trial 1:<\/h3>\n\n\n\n<p><strong>T\u00edtulo oficial:<\/strong> Effects of the Thyroid Hormone Analog Triac on the Neurocognitive Phenotype in Patients With Severe Psychomotor Retardation Caused by Mutations in the MCT8 Thyroid Hormone Transporter: The Triac Trial II<\/p>\n\n\n\n<p><strong>Descripci\u00f3n: <\/strong>\u00a0El ensayo actual (Triac Trial II) investigar\u00e1 si el tratamiento con Triac aporta una mejora del fenotipo neurocognitivo en pacientes con SAHD.<strong><br>Objetivo principal:\u00a0 <\/strong>Tratamiento<strong><br>Fecha de inicio prevista : <\/strong>Junio de 2018<strong><br>\u00a0Fecha de finalizaci\u00f3n prevista del ensayo :\u00a0<\/strong>Diciembre de 2022<strong><br>Ubicaci\u00f3n:\u00a0\u00a0 <\/strong>Erasmus Medical Center, Rotterdam<strong><br>Investigador principal: <\/strong>Dr. W.E. Wisser, Erasmus Medical Center<strong><br>Estado de reclutamiento:\u00a0<\/strong>ahora reclutando<strong><br>P\u00e1gina web:\u00a0<\/strong><a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02396459\">https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02396459<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Trial 2:<\/h3>\n\n\n\n<p><strong>Denominaci\u00f3n del ensayo cl\u00ednico:<\/strong> Rescue of Infants With Mct8 Deficiency Under Emergency Use Single Patient Expanded Access Treatment<br><strong>Descripci\u00f3n:<\/strong> La deficiencia de MCT8 (tambi\u00e9n conocida bajo el nombre de \u00abs\u00edndrome de Allan-Herndon-Dudley\u00bb) es un trastorno hereditario poco frecuente ligado al cromosoma X que afecta el desarrollo cerebral, causando discapacidades intelectuales graves y problemas de movimiento.<br><strong>Ubicaci\u00f3n:\u00a0<\/strong>\u00a0University of Miami, Miller School of Medicine, Florida, Estado Unidos<br><strong>Investigador principal:<\/strong> Roy E Weiss, M.D.<br><strong>Medicamento: <\/strong>Diiodothyropropionic acid\u00a0\u00a0(DITPA)<br><strong>P\u00e1gina web:<\/strong>\u00a0<a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04143295\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04143295<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Past Clinical Trials<\/h2>\n\n\n\n<p><strong>Thyroid Hormone Analog Therapy of Patients With Severe Psychomotor Retardation Caused by Mutations in the MCT8 Thyroid Hormone Transporter: The Triac Trial.rial.<\/strong><\/p>\n\n\n\n<p><strong>Descripci\u00f3n:<\/strong><\/p>\n\n\n\n<p>El ensayo actual investigar\u00e1 si el tratamiento con Triac en pacientes con SAHD:<br>1. reduce los efectos t\u00f3xicos de los niveles elevados de la T3<br>2. Restablece la deficiencia local de HT en el cerebro.<\/p>\n\n\n\n<p><strong>Objetivo principal: <\/strong>Tratamiento<br><strong>Fecha de inicio del ensayo:&nbsp;<\/strong>Octubre de 2014<br><strong>Fecha de finalizaci\u00f3n prevista:&nbsp; <\/strong>&nbsp;Mayo de 2018<br><strong>Ubicaci\u00f3n:<\/strong>&nbsp; Erasmus Medical Center, Rotterdam<br><strong>Investigador principal: <\/strong>Dr. W.E. Wisser, Erasmus Medical Center<br><strong>Estado de reclutamiento: <\/strong>Activo, no reclutando<br><strong>P\u00e1gina web:<\/strong> <a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02060474\">https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02060474<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ensayos cl\u00ednicos en curso Trial 1: T\u00edtulo oficial: Effects of the Thyroid Hormone Analog Triac on the Neurocognitive Phenotype in Patients With Severe Psychomotor Retardation Caused by Mutations in the MCT8 Thyroid Hormone Transporter: The Triac Trial II Descripci\u00f3n: \u00a0El ensayo actual (Triac Trial II) investigar\u00e1 si el tratamiento con Triac aporta una mejora del [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":395,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-271","page","type-page","status-publish","has-post-thumbnail","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.4 - 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